Buy Factive (Gemifloxacin) quinolone antibacterial medication
Cheap qualitative Gemifloxacin Mesylate 320 mg tablets online
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FACTIVE (GEMIFLOXACIN MESYLATE) TABLETS: PRESCRIBING INFORMATION
Factive (Gemifloxacin Mesylate) is a synthetic broad-spectrum antibacterial agent for oral administration. Gemifloxacin, a compound related to the fluoroquinolone class of antibiotics, is available as the mesylate salt in the sesquihydrate form. Chemically, gemifloxacin is (R,S)-7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid.
The mesylate salt is a white to light brown solid with a molecular weight of 485.49. Gemifloxacin is considered freely soluble at neutral pH (350 mcg/mL at 37°C, pH 7.0). Its empirical formula is C18H20FN5O4·CH4O3S.
Each white to off-white, oval, film-coated Factive tablet has breaklines and GE 320 debossed on both faces and contains gemifloxacin mesylate equivalent to 320 mg gemifloxacin. The inactive ingredients are hydroxypropyl methylcellulose, crospovidone, magnesium stearate, polyethylene glycol, microcrystalline cellulose, povidone, and titanium dioxide.
Factive clinical pharmacology
PHARMACOKINETICS IN SPECIAL POPULATIONS
Factive pharmacokinetics in special populations
Factive drug-drug interactions
Factive susceptibility tests
Factive animal pharmacology
Factive clinical studies
INDICATIONS AND USAGE
Factive indications and usage
Factive (Gemifloxacin) tablets are contraindicated in patients with a history of hypersensitivity to gemifloxacin, fluoroquinolone antibiotic agents, or any of the product components.
Factive special warnings
Factive drug interactions
Factive nonclinical toxicology
USE IN SPECIFIC POPULATIONS
Factive use in specific populations
Factive adverse reactions
Any signs or symptoms of overdosage by Gemifloxacin (Factive) should be treated symptomatically. No specific antidote is known. In the event of acute oral overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage; the patient should be carefully observed and treated symptomatically with appropriate hydration maintained. Hemodialysis removes approximately 20 to 30% of an oral dose of gemifloxacin from plasma.
Mortality occurred at oral gemifloxacin doses of 1600 mg/kg in rats and 320 mg/kg in mice. The minimum lethal intravenous doses in these species were 160 and 80 mg/kg, respectively. Toxic signs after administration of a single high oral dose (400 mg/kg) of gemifloxacin to rodents included ataxia, lethargy, piloerection, tremor, and clonic convulsions.
DOSAGE AND ADMINISTRATION
Factive dosage and administration
Factive (Gemifloxacin Mesylate) is available as white to off-white, oval, film-coated tablets with breaklines and GE 320 debossed on both faces. Each tablet contains gemifloxacin mesylate equivalent to 320 mg of gemifloxacin.
320 mg Unit of Use (CR*) 5's
320 mg Unit of Use (CR*) 7's
Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature]. Protect from light.
Manufactured and distributed by LG Life Sciences, Oscient Pharmaceuticals companies, and their divisions.
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